Lu, L., J. Jiang, M. Zhan, H. Zhang, Q. T. Wang, S. N. Sun, X. K. Guo, H. Yin, Y. Wei, J. O. Liu, S. Y. Li, Y. Li and Y. W. He (2021). "Targeting Neoantigens in Hepatocellular Carcinoma for Immunotherapy: A Futile Strategy?" Hepatology 73(1): 414-421.

We discussed the limits of using neoantigens as targets in HCC immunotherapy and suggested alternative strategies to overcome these limits. The first strategy is to explore other types of neoantigens derived from largely untapped sources. The second strategy involves tumor manipulation to enhance neoantigen generation, expression, and presentation.